HBEGF and pulmonary emphysema: These data were complemented by a genetic depletion model resulting in eosinophil cell death, with PHIL mice endogenously expressing the diphtheria toxin receptor under the control of the eosinophil peroxidase promoter.35 Eosinophil reduction resulted in a notable decrease in emphysema in PHIL mice compared to wild-type controls (Fig. 5f, g).