Consequently, the lung’s connective tissue undergoes elastin degradation, a phenomenon primarily linked to the advancement of emphysema.4 Elastase-induced emphysema brings about histological and morphological traits akin to those observed in panacinar emphysema.5 Our exploration utilizing multiple models of elastase instillation demonstrated that repeated exposure to elastase significantly triggers lung eosinophilia and consequent emphysematous changes;6 nonetheless, the exact mechanisms and roles played by eosinophils in these processes remain to be fully illuminated. This evidence concerns the gene ELN and pulmonary emphysema.