The metastasis of tumor cells in lung in xenograft nude mice was measured using anti-Ki67 staining, however, Ki67-positive cells were affected by neither RNF5 depletion nor by EphA2 depletion (Fig. S2), indicating that RNF5 depletion and EphA2 depletion did not inhibit MCF7-derived tumor cell migration in vivo. Here, RNF5 is linked to neoplasm.