Among these, Sanchez-Vega et al. [27] highlighted ten oncogenic signalling pathways that are most frequently altered in most human cancers (HIPPO, MYC, NOTCH, NRF2, PI3K, RTK/RAS, TGFβ, P53, WNT and cell cycle), and are mainly involved in promoting cell proliferation. This evidence concerns the gene PIK3CA and cancer.