The characteristic phenotype of HbE-β+-thalassemia usually presents as mild-to-moderate anemia (Hb levels ranging from 7.0–9.0 g/dL), markedly low MCV and MCH, and elevated HbF expression (>10% of total Hb) with Hb analysis exhibiting an EFA pattern [2,26]. This evidence concerns the gene GSTM1 and anemia (phenotype).