NFE2L2 and ischemia: The antioxidant mechanism of fullerol involves the up-regulation of phase II antioxidant enzymes which was modulated by nuclear factor erythroid 2-related factor 2 (Nrf2), and it was confirmed in H2O2-induced apoptosis of alveolar epithelial cells [15], ischemia-reperfusion induced myocardial injury [16], and UVB-induced cornea injury [14].