From prior publications, prevention of adipocyte dedifferentiation into protumorigenic myofibroblast-like, precursor cells (28), inhibition of angiogenesis (9), and polarization of macrophages toward an anti-inflammatory, debris-clearing state (29) stand out as critical antitumor properties of PPARγ-directed therapy that may also be compromised during tumor progression (Fig. 7F). Here, PPARG is linked to neoplasm.