Since podocyte injury is a critical step towards glomerular lesions in ADR-induced nephropathy and podocyte damage is involved in the loss of the permselective function of the glomerular filtration barrier, WT and Sirt3-/- renal tissues were stained with the podocyte marker WT1 and glomerular podocyte density was measured. This evidence concerns the gene SIRT3 and kidney disorder.