METTL3 promotes ferroptosis of VSMCs by downregulating key ferroptosis regulatory proteins, solute carrier family 7 member 11 (SLC7A11) and ferroptosis suppressor protein 1 (FSP1); while the specific inhibitor of ferroptosis can alleviate the development and rupture of aortic dissection in vivo [177]. This evidence concerns the gene SLC7A11 and Aortic dissection.