Regarding the impact of obesity on sarcopenia, there exists a proposition that an asymmetry between inhibitory factors involved in muscle growth, such as TGFβ, myostatin, activins, and others, in comparison to stimulatory factors like BMPs, BDNF, irisin, and FST, plays a substantial role in the development of sarcopenia [222]. Here, FNDC5 is linked to sarcopenia.