NR1D1 and epilepsy: 1. Circadian information improves the prediction ability.2. The rhythm of EEG signals is a promising biomarker for seizures.3. Clock the drugs: integrating pharmacokinetics and seizure times based on differential dosing times.4. Formulating drug administration plans based on chronopharmacokinetics and chronopharmacodynamics.5. Regulating endogenous/external signals of the circadian rhythm (eg., melatonin, diet and light) can reduce the seizures.6. Targeting CCGs (eg., REV-ERBα) is a promising therapeutic target in epilepsy.