PRODH knockout mice, which were originally crossed between the 129/ReJ and C57BL/6J strains, have been reported to exhibit significant attenuation in the overall level of prepulse inhibition [41], which is a reliable index for probing the neurobiology and genetics of gating deficits in schizophrenia both in humans and rodents [42]. Here, PRODH is linked to schizophrenia.