PKM and neoplasm: As shown in Figure 6C–6F, CCK8 assay and colony formation assay results showed that UCHL1 shRNAs treatment remarkably reduced tumor cell proliferation, while concomitant transfection of PKM2 overexpression vectors reversed the effects of UCHL1 shRNAs, and vice versa. Subsequently, we detected the impact of PKM2 modulation on cellular mobility using Transwell and wound healing assay.