And the results found the CNV frequency of ERGs was generally more than 5% in most cancer types except thyroid carcinoma (THCA), the CNV types of genes CAV1, BCL2L1, CEBPB, IGFBP1, SERINC3, COPS5, and PTPN1 were mainly amplification; the CNV types of gene BRSK2 were mainly deletion; and the CNV types of most ERGs in uterine carcinosarcoma (UCS) and testicular germ cell tumors (TGCT) were mainly amplification, which was the opposite trend in diffuse large B-cell lymphoma (DLBC) and kidney renal papillary cell carcinoma (KIRP) (Figure 2D). Here, COPS5 is linked to cancer.