LEF1 and esophageal squamous cell carcinoma: According to the ESOMIR database, the interaction between miRNA–mRNA networks in different signaling pathways is crucial in facilitating cross talks, for example, miR-34a-5p inhibits proliferation, migration, invasion and epithelial–mesenchymal transition in ESCC by targeting LEF1 and inactivating the Hippo–YAP1/TAZ Signaling Pathway (72).