TSC22D3 and fibrosis: As demonstrated by the analysis of the functional assay of fibrosis with PAO (Fig. 1c), the administration of bleomycin caused an increase in airway stiffness in Vehicle WT and GILZ KO mice in comparison to the Naïve group; the JNJ treatment reduces this airway stiffness in WT animals, as already demonstrated [10, 11, 42]; in GILZ KO mice, this effect is less evident for the absence of GILZ protein, demonstrating that the effect of JNJ is mediated by GILZ.