Ninety-five percent of NPC cases are caused by variants in the NPC1 gene (Carstea et al., 1997), encoding an endolysosomal 13-pass transmembrane protein containing a sterol-sensing domain (Iannou, 2000; Long et al., 2020; Millard et al., 2005). Here, NPC1 is linked to nasopharyngeal carcinoma.