SIX1 and Nephroblastoma: Wegert et al. (2015) provided the first mechanistic investigation of the SIX1-Q177R mutant protein by using ChIP-seq, demonstrating a shift in the DNA-binding motif for SIX1-Q177R when compared to that of wild-type SIX1 in primary Wilms tumor tissues. Increased binding of SIX1-Q177R was observed near the TGFA gene with corresponding elevated expression of TGFA in SIX1-Q177R mutant tumors compared to tumors comprising wild-type SIX1 (Wegert et al., 2015).