To more broadly characterize the potential regulatory activities of SIX1 and SIX1-Q177R in Wilms tumors, GO analysis was performed by using GREAT with the following motif-enriched Wilms tumor ChIP-seq peak sets: peaks exclusive to the SIX1-Q177R dataset (9483 peaks), peaks exclusive to the SIX1 dataset (9759 peaks), and peaks shared by both SIX1-Q177R and SIX1 datasets (7984 peaks) (Table S3). The gene discussed is SIX1; the disease is Nephroblastoma.