Furthermore, the SIX1-Q177R tumor that was used to generate the ChIP-seq data was homozygous for the mutation, while the overwhelming majority of SIX1/2-Q177R tumors in the microarray and RNA-seq datasets harbored heterozygous mutations (Wegert et al., 2015; Walz et al., 2015). The gene discussed is SIX1; the disease is neoplasm.