The finding that some podocyte-associated genes including WNT5A are specifically upregulated in SIX1/2-Q177R blastemal tumors, and that the canonical podocyte lineage-specific markers MAFB and PODXL colocalize with SIX1 and WNT5A in Wilms tumor tissue is intriguing when considered within the framework of the NPC differentiation continuum. The gene discussed is SIX1; the disease is Wilms tumor.