In the context of Wilms tumor, an investigation of chromatin profiles included WNT5A in a set of genes alongside core NPC genes SIX2, GDNF, EYA1 and OSR1 that were characterized by broad H3K4me3 domains (>3.5 kb) within 2.5 kb of the gene promoter in Wilms tumors, illustrating that the WNT5A promoter/gene is typically active in these tumors (Aiden et al., 2010). This evidence concerns the gene SIX2 and Wilms tumor.