One of the genes within this family, HNRNPU, which encodes for Heterogeneous Nuclear Ribonucleoprotein U [also known as Scaffold Attachment Factor A (SAF-A)] (Kiledjian and Dreyfuss, 1992), has emerged as a frequently affected gene leading to NDDs such as intellectual disability (ID), autism spectrum disorder (ASD) as well as neurological conditions such as epilepsies (Depienne et al., 2017; Satterstrom et al., 2020; Taylor et al., 2022). This evidence concerns the gene HNRNPU and epilepsy.