The aims of this study were, using WT and GluN2D‐KO mice, to determine the role of the GluN2D subunit in a range of schizophrenia‐relevant behaviors; examine if the psychotomimetic NMDAR antagonists PCP, R‐norket, and S‐ket elicited distinct responses; and identify if these showed sexual dimorphism. The gene discussed is GRIN2D; the disease is schizophrenia.