While PCP and RS‐ket have been reported to have sexually dimorphic effects on anxiety and cognitive behaviors (Fitzgerald et al., 2021; Liang et al., 2014; Turgeon et al., 2011), the role of the GluN2D subunit in mediating the effects of PCP or the ketamine enantiomers (R‐ket or S‐ket) has not been thoroughly investigated in both sexes to date. The gene discussed is GRIN2D; the disease is Anxiety.