PRDX4 has been reported to ameliorate lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy[63] but has never been studied in the gastrointestinal tract.NDUFAB1 encodes one of the mitochondrial respiratory chain complexes, which plays an essential role in mitochondrial homeostasis in colitis[64]. Here, PRDX4 is linked to diabetic cardiomyopathy.