COX6A1 is involved in oxidative phosphorylation and mitochondrial respiration [59,60] , but to date, its engagement in IBD has never been reported.PPIB helps to adapt cells to oxidative stress and hypoxic conditions[61] but has not been studied in IBD.ARF4 has been demonstrated to have anti-apoptotic activity in glioblastoma by inhibiting stress-mediated apoptotic signals[62]. This evidence concerns the gene ARF4 and glioblastoma.