The GI symptoms are contributed by the small intestine in addition to the stomach. Diabetic gastroenteropathy is multifactorial and involves not only parasympathetic and sympathetic autonomic nerves, but also enteric neurons, smooth muscle cells, and ICCs [19]. In addition to the factors mentioned above, delayed gastroenteropathy in diabetes mellitus (DM) is associated with hyperglycemia; incretin-based medications are used to stabilize postprandial blood glucose. This evidence concerns the gene GCG and diabetes mellitus.