Regarding the possible relationship between TNF-α and the intrathecal synthesis of Immunoglobulin (revealed as OCB) in our MS patients, it has been demonstrated that, during MS disease, B cells and/or plasma cells produce pro-inflammatory cytokines (IL-6, LTα, and GM-CSF), including TNF-α, with a deficient production of anti-inflammatory cytokines. The gene discussed is IL6; the disease is myeloid sarcoma.