This research has discovered combined detection of CASP3, ITGA1 and GSTM1 gene polymorphisms is provided with predictive value for GCC’s prognosis, clarifying that detection of CASP3, ITGA1 and GSTM1 gene polymorphisms is available to be adopted to early assess GCC patients’ prognosis. Here, CASP3 is linked to goblet cell carcinoma.