Logistic regression analysis has elaborated smoking, anxiety, HP infection, family history of gastrointestinal tumor, combination with chronic gastric disease, CASP3 and GSTM1 gene polymorphisms are risk factors for GC, and the reasons are as follow: GSTM1 is available to influence the detoxification ability of individuals to environmental carcinogens, elevated ITGA1 is available to augment gastrointestinal mucosa inflammation, CASP3 is available to mediate cell apoptosis, and multi-gene interaction is available to further boost GC’s occurrence [14]. This evidence concerns the gene CASP3 and Anxiety.