In the GC, the proportion of patients with aberrant BMI, smoking, anxiety, helicobacter pylori (HP)infection, family history of gastrointestinal tumor, combination with chronic gastropathy, CASP3 gene rs12108497 locus TC/CC type, ITGA1 gene rs1862610 locus AC/AA type, GSTM1 gene blank type was elevated vs. the control (P < 0.05), as manifested in Table 2. This evidence concerns the gene ITGA1 and digestive system neoplasm.