Numerous new biomarkers that indicate AKI earlier than serum creatinine are available, such as cell cycle arrest markers like tissue inhibitor of metalloproteinases 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7), and neutrophil gelatinase-associated lipocalin (NGAL). The gene discussed is IGFBP7; the disease is acute kidney injury.