IL17A and colorectal carcinoma: By analyzing the public CRC cell line transcriptome data, we found that F. nucleatum infection mainly affected the biological functions of epithelial-mesenchymal transformation, cell adhesion, cadherin binding, IL-17 signaling pathway, cytoskeletal motor activity, glycolysis, and fat metabolism, all of which has been validated by pervious studies [13, 14, 42–48].