In conclusion, our work highlights the pathogenic role of MAGEA2-mediated tumor-stromal crosstalk in PDAC chemoresistance and progression, supporting that targeting multiple MAGEA antigens with a DNA vaccine in one goal can eliminate chemoresistant PDAC tumor cells, and provide the first promising immunotherapy for chemoresistant pancreatic cancer. The gene discussed is MAGEA2; the disease is familial pancreatic carcinoma.