Notably, our analysis has singled out two central lncRNA-miRNA-mRNA axes, specifically, KRTAP5-AS1-hsa-miR-30b-5p-PNN and XIST-hsa-miR-511-3p/hsa-miR-1277-5p-F2RL1, which represent putative RNA regulatory pathways instrumental in modulating the progression of RA. The gene discussed is PNN; the disease is rheumatoid arthritis.