Among these, the axes KRTAP5-AS1-hsa-miR-30b-5p-PNN and XIST-hsa-miR-511-3p/hsa-miR-1277-5p-F2RL1 have been identified as key lncRNA-miRNA-mRNA axes that may play a significant role in the pathogenesis of RA. The gene discussed is F2RL1; the disease is rheumatoid arthritis.