In the Insulin Resistance Atherosclerosis Study (IRAS) of glycemia, insulin resistance, and insulin secretion involving 1,225 multiethnic participants with or without diabetes, positive correlations were observed between inflammatory markers — GlycA and GlycB (r = 0.74), GlycA and hsCRP (r = 0.60), and GlycB and hsCRP (r = 0.46) (all p < 0.001) — that differentially stratified more advanced disease (i.e. impaired glucose tolerance and T2D) from normal or a susceptible clinical phenotype (i.e. normal glucose response and isolated impaired fasting glucose) [27]. This evidence concerns the gene INS and type 2 diabetes mellitus.