In the Metabolic Syndrome in Men (METSIM) study including 5,401 Finnish men with no history of T2D who were followed for a median of 6.8 years, GlycA was associated with impaired insulin secretion, hyperglycemia and incident T2D, whereas IL-1 receptor antagonist and hsCRP were associated with reduced insulin sensitivity and increased total mortality [55]. This evidence concerns the gene INS and Hyperglycemia.