IL6 and Sepsis: However, we add to this finding, (a) by identifying the nearly linear association with particle concentration of small HDL, but nonlinear association with particle concentration of medium/large HDL, (b) providing more precision around estimates, (c) using genetic data, which did not support a causal relationship between total HDL and small HDL on risk of sepsis, and (d) adding further analyses on causal relationship with IL-6 signalling explaining the relationship between low number of small HDL particles and increased risk of sepsis.