Metabolic surgery is the most efficacious, with a maximum remission rate of approximately 70–80% at 1–2 years after surgery [3, 4], followed by lifestyle interventions with caloric restriction, with a 40–80% average remission rate at 1 year after intervention [5], and intensive insulin therapy, which can also provide remission in 30–70% of patients with T2DM [6, 7]. This evidence concerns the gene INS and type 2 diabetes mellitus.