SMAD2 and neoplasm: The results (Fig. 5b) showed that the expression of PCBP2 protein in tumor tissues decreased with the increase of drug concentration; compared with the control group, the protein content in C group (20 mg/kg) was decreased; the content of FHL3 protein in C (20 mg/kg) group was higher than that in Control group; the changes of TGF-β1, P-Smad2 and P-smad7 proteins were similar to those of PCBP2, and all showed a downward trend.