At last, immunohistochemical results further proved that Curcusone C induced the decreasing expression of PCBP2, TGF-β1, P-Smad2 and P-smad7 and increasing expression of FHL3 in nude mouse tumors, and inhibited tumor cell growth, proliferation and metastasis in nude mice. The gene discussed is PCBP2; the disease is neoplasm.