Our results suggested that Curcusone C disrupt the Bax/Bcl-2 balance in PC-3 cells by inhibiting the expression of the target protein PCBP2, thereby inducing mitochondrial damage and activation of the mitochondrial apoptosis pathway, and ultimately inducing apoptosis of prostate cancer cells, which was similar with the research of Zhang et al. as mentioned before [11]. Here, BCL2 is linked to Familial prostate cancer.