In addition, combined with the results of in vitro mechanism experiments, we selected PCBP2, FHL3, TGF-β1, phosphorylated Smad2 and phosphorylated Smad7 as the research objects of anti-tumor mechanism in vivo, and immunohistochemistry was used to detect the changes of protein expression in tumor tissues after drug treatment. The gene discussed is SMAD2; the disease is neoplasm.