CDK4 and leukemia: To figure out how miR-1246 and CADM1 participated in the regulation of cell cycle distribution in chemo-resistant leukemia cells, the cell cycle related genes, including CDK2, CDK4, Cyclin D1 and Cyclin E, were focused on in the presence or absence of miR-1246 inhibition or interference with CADM1 in chemo-resistant or -sensitive leukemia cells.