In the previous studies, miR-205-3p down-regulated CXCL11 protein and inhibited Akt signalling activation thereby hindering GC cell proliferation and invasion [7], while miR-205-3p was significantly increased in NSCLC tissues by targeting APBB2 to promote NSCLC progression [21], the results demonstrate that miR-205-3p plays a role as a pro-oncogenic factor in NSCLC, possibly due to the opposite effects of miR-205-3p in different tumor cells. The gene discussed is APBB2; the disease is neoplasm.