The significant prognostic factors in the univariate analysis were serum albumin (P = 0.005), serum AFP (P = 0.018), serum PIVKAII (P = 0.049), tumor number (P = 0.013), tumor size (P = 0.001), vascular invasion (P < 0.001), liver cirrhosis (P = 0.012), and Wnt5a/ROR2 expression (Wnt5a–ROR2− vs Wnt5a+ROR2+; P = 0.035). This evidence concerns the gene AFP and cirrhosis of liver.