In addition, we also analyzed the correlation between bone-marrow blast and coagulation indicators in B-ALL patients, and found initial tumor burden was moderately positively correlated with peak PT (r= +0.63; 95% CI, 0.18–0.82; P=0.010) and peak ATIII (r= +0.5147; 95% CI, 0.01–0.81; P=0.044), while negatively correlated with PLT nadir. The gene discussed is SERPINC1; the disease is acute lymphoblastic leukemia.