Yet, indications of how modifiable SV2A is in the human brain may potentially be derived indirectly: A study on SV2A binding in cocaine-use disorder by Angarita et al. [53] found a negative correlation between [11C]UCB-J binding and duration of cocaine abstinence, whereas years of lifetime use was unrelated to SV2A binding. Here, SV2A is linked to cocaine use disorder.