First, the type 2 diabetes-associated SNP rs1042725 in the HMGA2 locus has a higher odds ratio in the top quartile of CVD topic weight (1.18 ± 0.02) than in the bottom quartile (1.00 ± 0.02; P = 3 × 10−4 for interaction test (FDR = 0.04 < 0.1); P = 3 × 10−7 for top/bottom quartile test (FDR = 0.0002 < 0.1)). This evidence concerns the gene HMGA2 and type 2 diabetes mellitus.