Furthermore, when CD8+ Teff cells matured into CD8+ Tmem cells 30 d after LCMV Armstrong infection, the expression of the malate shuttle-associated genes decreased to levels comparable to those in naïve T cells, and this response was accompanied by decreased expression of Pdcd1, Rgs16 and Lag3 and reexpression of Tcf7, Sell and Il7r. Persistent LCMV clone 13 infections induced and maintained the expression of Got1, Got2, Mdh1 and Mdh2, in an expression pattern resembling that of Pdcd1, Rgs16 and Lag3 (Fig. 1a). This evidence concerns the gene LAG3 and infection.