We report, that the maximal peptide ratios of complement components (3, 1, 4a, 5, 7, 9), interleukins (IL1, IL16, IL17, IL18, IL36), and programmed cell death proteins (PD2, PD4) were higher in both NK and JK from Gipie-silenced cancer-immune co-culture subsets, with the converse seen in complement components C1q, PD5 (PDCD5), and PD10 (PDCD10) (Fig. 3I). The gene discussed is IL18; the disease is cancer.