Similarly, significant increase in the maximal peptide ratio of granzyme, 214%: ACC−/−/NK versus ACC/NK (P ≤ 0.001, 95% CI 359.9, 798.1) and perforin, 232%: ACC−/−/NK versus ACC/NK (P ≤ 0.0001, 95% CI 25.28, 60.92) (Fig. 3J,K). This evidence concerns the gene PRF1 and adrenal cortex carcinoma.