CST3 and Hypertension: In the ESUS cohort, older age (62 [56–69] vs 58 [51–66], p = 0.014), and lower female incidence (30% vs. 42%), higher incidence of hypertension, higher glycated hemoglobin and cystatin c, more WMHs, lacunae and EPVSs, and higher CSVD burden were found in IAP compared to patients without.