In the ESUS cohort, older age (62 [56–69] vs 58 [51–66], p = 0.014), and lower female incidence (30% vs. 42%), higher incidence of hypertension, higher glycated hemoglobin and cystatin c, more WMHs, lacunae and EPVSs, and higher CSVD burden were found in IAP compared to patients without. This evidence concerns the gene CST3 and hypertensive disorder.