As expected, after 24 h, AZ960 and A12232 treatment of HCC cells caused significant decreases in PD-L1 mRNA and protein expression compared with no treatment (Supplemental Fig. 2A, B).In addition, we treated the HCC-LM3 cell with shTUG1 and/or JAK2/STAT3 overexpression, and evaluated the levels of PDL1. The gene discussed is STAT3; the disease is hepatocellular carcinoma.