The deleterious variants of BRCA1/2 genes, such as c.5558dupA (BIC: 5677insA) in BRCA1 (ref. 36) and c.9541_9554del14 (BIC: 9769del14) in BRCA2, abrogate the function of encoded proteins, and confer a high risk of breast (most commonly the TNBC subtype) and ovarian cancers [37]. The gene discussed is BRCA1; the disease is ovarian carcinoma.