More important, as shown in Fig. 2B, the mortality rate of tumor cells in CDCA8 knockdown group was considerably increased by using TUNEL staining, and the HE staining showed the degree of nucleus atypia in CDCA8 knock-down team was lower, in addition, we verified that CDCA8 was indeed hypo-expressed in the CDCD8 knockdown team. The gene discussed is CDCA8; the disease is neoplasm.