Consistent with these findings, CD8 T cells that were incubated with gRNA-Cebpb gRNA-Med12 double KO BMDCs, had higher expression of interferon, Gzmb, and perforin, and low expression of Lag3. These alterations in gene expression and cytokine secretion (Figs. 5 and 6) suggest enhanced cancer cell-killing potential, although we did not assess cancer cell-killing directly. Here, PRF1 is linked to cancer.