To elucidate the relationship and underlying mechanisms between JMJD5 and EGFR, we first established JMJD5 stably overexpressed NSCLC cell lines (A549 cells with high expression of WT-EGFR; H1650 and H1975 cells with EGFR E19del or EGFRL858R/T790M, respectively) and examined EGFR expression. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.