Both rs17849502 (NCF2 gene, substitution His389Gln) and rs13306575 (NCF2 gene, substitution Arg395Trp) were strongly associated with SLE in North Americans of Hispanic descent (p = 4.91 × 10-9 and 1.50 × 10-11, respectively). Here, NCF2 is linked to systemic lupus erythematosus.