These SNPs represented three distinct genes: NCF2, TYK2, and DNASE1L3. The NCF2 gene with the SNP rs13306575 was predicted having possibly damaging by increasing the possibility of having SLE, while the SNP rs17849502 in this gene was predicted to be probably damaging at the protein level. The gene discussed is TYK2; the disease is systemic lupus erythematosus.