PDE6D and familial pancreatic carcinoma: Given the high affinity of the K-Ras4BG12D/PDE6δ and KRas4BG12C/PDE6δ complexes for C14 and the importance of these complexes in pancreatic cancer maintenance and progression, we performed viability assays to measure the cytotoxic effect of C14, using the PDAC cell lines PANC-1 and MIA PaCa-2, because these cell lines present the KRas4G12D mutation which has the highest frequency in PDAC, the normal pancreatic duct cell line hTERT-HPNE al cells were also used as cytotoxic specificity controls, because they are non-cancerous cells.