ARSB and neoplasm: Total chondroitin sulfate tumor content was 14.25 ± 0.91 μg/mg protein in the control mice, compared to 9.43 ± 0.64 μg/mg protein (p = 0.03, n = 6 per group) in the mice treated with exogenous ARSB 0.2 mg/kg on days 2, 7, 14, and 21 (Fig. 2A).