Hotspot mutations in the GNAQ/GNA11, BRAF, and pTERT genes are useful for differentiating melanotic schwannoma (wild type) from melanocytoma (typically a GNAQ/GNA11 mutation) and cutaneous melanoma (typically a BRAF or pTERT mutation).20, 21 Epigenetic analyses using genome-wide methylation profiles emerge as an excellent tool to differentiate groups of biologically distinct tumors. The gene discussed is GNA11; the disease is cutaneous melanoma.