INS and Insulin resistance: Accordingly, in a proof-of-principle trial in humans with insulin resistance, we gathered evidence in support of the hypothesis that supplementation with KDP could promote a more reduced (antioxidant effect) erythrocyte and skeletal muscle redox state monitored via the oxidation status of GSH and PRX, which would associate with improved blood-glucose clearance and insulin sensitivity within measures of primary skeletal muscle nutrient delivery pathways, including microvascular blood flow [20], insulin-receptor signalling and glucose transporter 4 (GLUT4) translocation [21].